Clone of Week 4 | Pathophysiology of Wound Healing (15171-SP)

Illustration of a macrophage.

Content Outline

  • Brief review of complexity of normal healing and systems affected by pathological changes.
    • Timing of cell migration to site of injury
    • Major cells and proteins involved in healing
      • Platelets
      • Leukocytes
      • Lymphocytes
      • Fibroblasts
      • Vascular endothelial cells
      • Epithelial cells
      • Growth factors
      • Adhesion molecules
    • Components of the wound matrix
  • Inflammation – Friend or Foe?
    • Role of Neutrophils
    • How microbes are destroyed by the non-specific immune system
    • Phagocytosis
    • Role of macrophages
    • Immune related tissue damage
  • Growth factors and alterations in non healing wounds
    • Roles and effects of growth factors
    • Cellular recognition of growth factors
    • Internal cellular responses to growth factor stimulation
  • Cell cycles
    • Normal
    • Changes in chronic wounds
    • Cellular senescence
  • Proteases
    • Roles in wound healing
    • Matrix metalloproteinases (MMP’s)
    • Tissue inhibitors of MMP’s
    • Importance to wound healing
  • Concept integration: Why wounds don’t heal
    • Healing trajectory
    • Acute wounds and healing problems
    • Chronic wounds and healing problems
    • Wounds/injury etiology
    • Tissue factors
    • Pathology
    • Recurrence
    • Local wound environment
      • Proteases, TIMPs
      • Growth factors
      • Bacteria
      • Cellular senescence

Objectives for Learning Outcomes

At the end of this course work the learner will be able to:

  1. Describe the roles of major cells, growth factors, MMP’s and TIMP’s in normal and delayed healing.

  2. Identify cellular changes (pathology) that contribute to chronic wounds.

  3. Compare and contrast acute and chronic local wound environments describing pathological changes that are associated with chronic wounds.

Additional Information

Course summary

JoAnne Whitney, PhD, RN, CWCN, FAAN
Certified Wound Care Nurse; Associate Dean for Research, Professor, Biobehavioral Nursing and Health System, University of Washington School of Nursing; Research Scientist, University of Washington Medicine/Harborview Medical Center, Seattle, WA

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