Week 3 | Wound Healing Physiology Part 1 and 2 (17170-SP)

Illustration of blood cells.

Content Outline

  • Physiology of Healing
    • Types of Healing
      • Primary
      • Secondary
      • Partial thickness
      • Full thickness
  • Major Wound Healing Phases
    • Hemostasis
    • Inflammation
    • Proliferation
      • Matrix
      • Angiogenesis
      • Epithelization
    • Remodeling
      • Collagen changes
      • Contraction
  • Cast of Cellular Characters
    • Platelets
    • Neutrophils
    • Monocytes/Macrophages
    • Fibroblasts
    • Vascular Endothelial Cells
    • Epithelial Cells
  • Hemostasis
    • Vascular responses
    • Immune activation
    • Platelet degranulation
    • Clot formation
    • Growth factor release
  • Cell signaling
    • Adhesion molecules
      • Transmembrane proteins
      • Intracellular signaling
    • Major families
      • Integrins
      • Selectins
      • CAMs
      • Cadherins
    • Role of Adhesion Molecules in Healing
      • Cell expression
      • Cellular interactions with CAM’s
    • Growth factors-molecular directors of healing
      • Proteins
      • Regulatory functions – cell migration, mitosis, gene expression, protein synthesis
    • Major Growth Factor Families Involved in Healing – family, sources, actions
      • Platelet derived growth factors (PDGF, VEGF)
      • Transforming Growth Factors – Beta
      • Fibroblast Growth Factors (FGF)
      • Insulin-like growth factor (IGF-1, IGF-2)
      • Epidermal growth factor (TGF-alpha, EGF)
  • Inflammation -- first 5 days after injury
    • Cellular infiltration by cell type
    • Provisional matrix-components and functions
    • Phagocytosis
    • Growth factor production
    • Clinical features
  • Tissue Proliferation – 7-21 days after injury
    • Matrix production
      • Wound module – what is it? How does it stimulate healing
      • Provisional matrix
      • Collagen production
        • Co-factors
        • Steps in synthesis by fibroblasts
        • Extracellular modifications and crosslinking
        • Differences in new versus mature collagen
      • Angiogenesis
        • Stimulatory signals within wound environment
        • Functions
        • Basement membrane changes and formation of capillary loops
        • Proteases
      • Epithelialization
        • Signals for cellular migration
        • Process of epithelial repair
  • Remodeling of the newly established matrix
    • Role of proteases
    • Changes in collagen
    • Wound strength

Objectives for Learning Outcomes

At the end of this course work the learner will be able to:

  1. Describe the phases of wound healing.
  2. Identify the major roles of the following cells and factors in healing: platelets, growth factors, cell adhesion molecules, leukocytes, macrophages, endothelial cells, epithelial cells, fibroblasts and myofibroblasts.
  3. Identify responses to injury that stimulate tissue repair.
  4. Discuss four major differences between the cellular characteristics of acute and chronic wounds and how these influence healing response

Additional Information

Format: 
Video
Course summary
Available: 
01/13/2017
Expires: 
04/30/2018
Part of: 
Wound Management Education Program (17170-SP)

JoAnne Whitney, PhD, RN, CWCN, FAAN
Certified Wound Care Nurse; Associate Dean for Research, Professor, Biobehavioral Nursing and Health System, University of Washington School of Nursing; Research Scientist, University of Washington Medicine/Harborview Medical Center, Seattle, WA

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