Week 3 | Wound Healing Physiology Part 1 and 2 (17170-SP)
Content Outline
- Physiology of Healing
- Types of Healing
- Primary
- Secondary
- Partial thickness
- Full thickness
- Types of Healing
- Major Wound Healing Phases
- Hemostasis
- Inflammation
- Proliferation
- Matrix
- Angiogenesis
- Epithelization
- Remodeling
- Collagen changes
- Contraction
- Cast of Cellular Characters
- Platelets
- Neutrophils
- Monocytes/Macrophages
- Fibroblasts
- Vascular Endothelial Cells
- Epithelial Cells
- Hemostasis
- Vascular responses
- Immune activation
- Platelet degranulation
- Clot formation
- Growth factor release
- Cell signaling
- Adhesion molecules
- Transmembrane proteins
- Intracellular signaling
- Major families
- Integrins
- Selectins
- CAMs
- Cadherins
- Role of Adhesion Molecules in Healing
- Cell expression
- Cellular interactions with CAM’s
- Growth factors-molecular directors of healing
- Proteins
- Regulatory functions – cell migration, mitosis, gene expression, protein synthesis
- Major Growth Factor Families Involved in Healing – family, sources, actions
- Platelet derived growth factors (PDGF, VEGF)
- Transforming Growth Factors – Beta
- Fibroblast Growth Factors (FGF)
- Insulin-like growth factor (IGF-1, IGF-2)
- Epidermal growth factor (TGF-alpha, EGF)
- Adhesion molecules
- Inflammation -- first 5 days after injury
- Cellular infiltration by cell type
- Provisional matrix-components and functions
- Phagocytosis
- Growth factor production
- Clinical features
- Tissue Proliferation – 7-21 days after injury
- Matrix production
- Wound module – what is it? How does it stimulate healing
- Provisional matrix
- Collagen production
- Co-factors
- Steps in synthesis by fibroblasts
- Extracellular modifications and crosslinking
- Differences in new versus mature collagen
- Angiogenesis
- Stimulatory signals within wound environment
- Functions
- Basement membrane changes and formation of capillary loops
- Proteases
- Epithelialization
- Signals for cellular migration
- Process of epithelial repair
- Matrix production
- Remodeling of the newly established matrix
- Role of proteases
- Changes in collagen
- Wound strength
Objectives for Learning Outcomes
At the end of this course work the learner will be able to:
- Describe the phases of wound healing.
- Identify the major roles of the following cells and factors in healing: platelets, growth factors, cell adhesion molecules, leukocytes, macrophages, endothelial cells, epithelial cells, fibroblasts and myofibroblasts.
- Identify responses to injury that stimulate tissue repair.
- Discuss four major differences between the cellular characteristics of acute and chronic wounds and how these influence healing response
Additional Information
Format:
Video
JoAnne Whitney, PhD, RN, CWCN, FAAN
Certified Wound Care Nurse; Associate Dean for Research, Professor, Biobehavioral Nursing and Health System, University of Washington School of Nursing; Research Scientist, University of Washington Medicine/Harborview Medical Center, Seattle, WA
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